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            Spermine 精胺
             產品貨號: SS3256
             產品名稱: Spermine 精胺
             產品價格/規格: 1g 300元
             產品說明書: 暫無
             更新時間: 2022-06-07
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            • Spermine 精胺


              N,N′-雙(3-氨基丙基)-1,4-丁二胺 精素 肌胺 肝胺

              • 線性分子式 NH2(CH2)3NH(CH2)4NH(CH2)3NH2

                 CAS:71-44-3
              • 分子量 202.34

              • 純度:>98%


              Biochem/physiol Actions

              Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
              Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

              多胺位點混合型 NMDA 谷氨酸受體激動劑/拮抗劑。在高濃度 (1mM) 下觀察到神經保護作用,而在低濃度下則觀察到神經毒性。它在番木鱉堿-不敏感性甘氨酸位點能夠增強激動劑效應。在細胞增殖和分化中發揮作用;抑制神經元一氧化氮合成酶 (nNOS)。


              1g  300元  Cat:SS3256


              貯存:2-8℃

              運輸:RT


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