• <output id="rvd5t"><small id="rvd5t"></small></output>

        <tr id="rvd5t"></tr>

          1. <th id="rvd5t"><sup id="rvd5t"></sup></th>
            免費咨詢電話: 400-699-0631      點擊這里給我發消息

            Amphotericin B solubilized可溶性兩性霉素B
             產品貨號: AE437
             產品名稱: Amphotericin B solubilized可溶性兩性霉素B
             產品價格/規格: 25mg 150元/100mg 540元
             產品說明書: 點擊查看
             更新時間: 2022-04-22
            詳細信息   訪問次數:

            • 產品介紹
            • 發表文章
            • 相關產品
            • 質檢證書

            • Amphotericin B solubilized from Streptomyces sp


              CAS Number: 1397-89-3  C47H73NO17  MW 924.08










              ● Storage:2-8°C

              ● Specification:

              Form…………………….fine, light yellow, lyophylized powder

              Stock solution………… 2.5mg/ml(以有效含量計算) in H2O

              ● Product description:

              Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols, primarily ergosterols, of fungal and bacterial cell membranes. After binding to sterols, it forms channels in the membranes, causing small molecules to leak out. Amphotericin B is effective against fungi and yeast. Normal usage for maintenance of cell cultures is 2.5 mg/l with penicillin and streptomycin in the medium. For cultures already contaminated with yeast and fungus, it is recommended to use this product at 2-4 times the normal level (5-10 mg/l), without penicillin and streptomycin for 2-3 subcultures. Once the infection is under control, normal maintenance levels of amphotericin B should be used. Amphotericin B is not soluble in H2O but in DMSO. Amphotericin B solubilized is a colloidal suspension of Amphotericin B, using sodium deoxycholate as the solubilizing agent. The product is approximately 45% amphotericin B, 35% sodium deoxycholate; the balance being sodium phosphate and sodium chloride.

              ● Preparation instructions:

              Amphotericin B solubilized is reconstituted at the water in a 2.5 mg/ml stock solution. The solution must be filtered to sterilize by 0.22μm membrane.

              ● Storage/Stability:

              The lyophylized powder amphotericin B solubilized can be stable for 5 years under -20℃ protected from air and light. Stock solutions at 2-8 °C are stable for up to 1 month.

              ● Reference:

              1. Bolard, J., Biochim. Biophys. Acta, 864: 257-304 (1986).

              2. Venegas, B., et al., Biophys. J., 85, 2323-32 (2003).

              3. Vertut-Doi, A., et al., Biochem. Biophys. Res. Commun., 157, 692-97 (1988).

              4. Sau K., et al., J. Biol. Chem., 278, 37561-68 (2003).

              5. Perlman, D., Methods Enzymol., 58, 110-16 (1979).


            中科瑞泰(北京)生物科技有限公司 版權所有 京ICP備12052607 網站管理   快遞查詢   IF查詢
            電話:010-58437227 免費電話:400-699-0631 傳真:010-57909566
            點擊這里給我發消息   內勤訂貨QQ:2446698252   技術支持QQ:460449375 電子郵箱:real-times@vip.163.com